10023416 R,T
Introduction: the epidemiology
of uterine leiomyomas
Uterine fibroids are the most
common tumors in women during the reproductive years, and are the most
frequent indication for hysterectomy in most countries in the world. This
paper discusses the socio-economic and social impact of these tumors. (US
fibroid-related costs in 1990 were $3 billion.)
1998 Baillieres Clin Obstet
Gynaecol 12;2:169-76
Vollenhoven, B.
11099869 JA
Heritability and risk factors
of uterine fibroids--the Finnish Twin Cohort study
Reproductive and body factors
may have at least as large a role in pathogenesis of fibroids as genetic
factors.
2000 Maturitas 37;1:15-26
Luoto, R., Kaprio, J., Rutanen,
E. M., Taipale, P., Perola, M., and Koskenvuo, M.
11864669 JA
Predictors of subsequent
surgery for uterine leiomyomata after abdominal myomectomy
In 65 women who had abdominal
myomectomy by the same surgeon, there was an increased risk of
subsequently needing a second surgery if the uterus was under 12 week size
at original surgery.
2002 Obstet Gynecol 99;3:426-32
Stewart, E. A., Faur, A. V.,
Wise, L. A., Reilly, R. J., and Harlow, B. L.
11890384 MCC
Complementary medicine
treatment of uterine fibroids: a pilot study
Matched case control study of
women with symptomatic fibroids treated with acupuncture, Chinese herbs,
nutritional therapy, pelvic bodywork (myofascial release and deep tissue
massage), meditation and guided imagery vs. conventional therapy with
hormonal manipulation and non-steroidal anti-inflammatory medication. Over
six months, fibroids disappeared, shrank or stayed stable in 22/37 of the
treatment group vs. 3/37 in the control group. However, both groups had an
equal decrease in symptoms of abnormal bleeding and cramping. Costs for
the treatment group were $3800/patient.
2002 Altern Ther Health Med
8;2:34-6, 38-40, 42, 44-6
Mehl-Madrona, L.
11890383 L
Etiology and treatment of
uterine fibroids
Comment on previous study, delineating the difficulties of providing
such a comprehensive array of complementary therapies, the time and costs
involved, practitioner knowledge base, potential problems with herbal
medicine, etc--especially in view of the fact that there was no difference
in symptoms of bleeding or cramping between the two groups. Author
calls for future well designed studies combining standard and
complementary therapies.
2002 Altern Ther Health Med
8;2:32-3
Chez, R. A.
Physiology
11035990 R,T
Influence of exogenous estrogen
receptor ligands on uterine leiomyoma: evidence from an in vitro/in vivo
animal model for uterine fibroids
Uterine leiomyomata show an
enhanced sensitivity to estrogen. Organochlorine pesticides, dietary
flavanoids, botanical extracts, and therapeutic antiestrogens can
influence fibroid growth.
2000 Environ Health Perspect
108 Suppl 5;829-34
Hunter, D. S., Hodges, L. C.,
Eagon, P. K., Vonier, P. M., Fuchs-Young, R., Bergerson, J. S., and
Walker, C. L.
11826769 JA
Different expression of
estrogen receptors alpha and beta in human myometrium and leiomyoma during
the proliferative phase of the menstrual cycle and after GnRHa treatment
Both alpha and beta estrogen
receptors were analyzed in fibroid as well as normal uterine myometrial
tissue. Alpha receptors were higher in the fibroid than the normal tissue.
After treatment with GnRHa, the alpha receptors were higher, and the betas
lower than normal tissue, leading to an increased alpha/beta ratio. This
increased ratio could reflect or be the cause of the shrinkage of the
fibroid.
2001 Gynecol Endocrinol
15;6:443-52
Wang, H., Wu, X., Englund, K.,
Masironi, B., Eriksson, H., and Sahlin, L.
7847524 R,T
Progesterone: a critical role
in the pathogenesis of uterine myomas
The transformation of
myometrium to fibroid involves mutation of normal uterine muscle cells and
a complex interaction of sex steroids and local growth factors. In
addition to estrogen, progesterone plays a role in growth.
1995 Am J Obstet Gynecol 172;1
Pt 1:14-8
Rein, M. S., Barbieri, R. L.,
and Friedman, A. J.
11035994 JA
Novel therapeutic strategies
for leiomyomas: targeting growth factors and their receptors
Analysis of fibroid cell
culture demonstrates several growth factors. Either the growth factors or
their receptor sites could be targeted for potential treatment.
2000 Environ Health Perspect
108 Suppl 5;849-53
Nowak, R. A.
9689356 JA
Interferon-alpha is a potent
inhibitor of basic fibroblast growth factor-stimulated cell proliferation
in human uterine cells
Interferon-alpha, an
anti-angiogenic cytokine, is a potent inhibitor of uterine cell
proliferation for fibroid, myometrial and endometrial stromal cells in
culture.
1998 Am J Reprod Immunol
40;1:19-25
Lee, B. S., Stewart, E. A.,
Sahakian, M., and Nowak, R. A.
10023418 R,T
Pathology of uterine fibroids
Review of the pathological
appearance of uterine fibroids on a macroscopic, histologic, and
ultrastructural level. Review also of the effects of GnRH agents on
fibroids, with "considerable variation in the pattern of response from
case to case and maybe even from tumour to tumour." Results ranged from no
change to necrosis.
1998 Baillieres Clin Obstet
Gynaecol 12;2:197-211
Crow, J.
