|
|
The focus of
this research database is on how stress affects women's health,
and
options for treatment using mind-body therapies.
If you are not a
health care professional, see new "Medical Glossary" below.
To obtain full
summaries of the articles, see "How to Get Abstracts" below.
Endometriosis
Psychology
Immune issues
Cancer issues
Psychology
1807364
JA
What is important to the
patient with endometriosis?
Women with endometriosis often
face a mixture of confusion, fear, grief, anger and self-guilt. Importance
of an open, understanding relationship between doctor and patient.
1991 Br J Clin Pract Suppl
72;8-10; discussion 11-3
Kennedy, S.
10451777 R,T
Endometriosis and pain
Thorough review of ways
endometriosis can cause pain, other disorders that can mimic endometriosis
pain, and overview of pain relief treatments. "Health-related quality of
life is significantly affected by endometriosis when pain is present. This
involves an inner relationship between the mind, body, general health
perception, bodily function, anxiety, depression, emotion, and social
functioning. The health care team must avoid what has been called "gynevision",
i.e. using a narrow focus on organic pathology."
1999 Clin Obstet Gynecol
42;3:664-86
Martin, D. C. and Ling, F. W.
8476817 CT
Short term psychological
outcome of surgical intervention for endometriosis
In this very limited,
uncontrolled study, 37 women who underwent laparoscopic treatment of their
endometriosis had significantly decreased pain, depression and anxiety at
three months post surgery.
1993 Br J Obstet Gynaecol
100;2:191-2
Low, W. Y., Edelmann, R. J.,
and Sutton, C.
9564669 JA
Importance of lay organizations
for coping with endometriosis
Responding to an internet
questionnaire, women with endometriosis benefited from connections to
other women with endometriosis. What they wanted most in a support network
was to be listened to and believed, and for their support system to be
knowledgeable about endometriosis and share information.
1998 J Reprod Med 43;3
Suppl:331-4
Whitney, M. L.
9443134 JA
Treatment of endometriosis
involving a self-help group positively affects patients' perception of
care
In establishing an
Endometriosis Clinic co-operatively between a group of Australian
gynecologists and the Endometriosis Association, a self-help group, 97% of
women felt that the consultation with a counselor form the Endometriosis
Association was a major source of satisfaction. There was high demand for
this concept of integration.
1997 J Psychosom Obstet
Gynaecol 18;4:255-8
Wingfield, M. B., Wood, C.,
Henderson, L. S., and Wood, R. M.
8488967 JA
MAST scores, alcohol
consumption, and gynecological symptoms in endometriosis patients
Women with endometriosis and
also women with other gynecological disorders scored significantly higher
than controls on an alcoholism screening test. However, when faced with
active gynecologic symptoms, women with endometriosis turned more
frequently to alcohol than women with other gynecologic disorders.
1993 Alcohol Clin Exp Res
17;2:272-8
Perper, M. M., Breitkopf, L.
J., Breitstein, R., Cody, R. P., and Manowitz, P.
[Top]
Immune issues
11476764
R,T
Treating endometriosis as an
autoimmune disease
Reviews the similarities
between endometriosis and autoimmune disorders in etiology and
pathophysiology, and suggests the potential for use of immunomodulators
(medications to alter the immune system)
for treatment.
2001 Fertil Steril 76;2:223-31
Nothnick, W. B.
11163805
R,T
Immunobiology of endometriosis
Review of humoral and cellular
immunology of endometriosis. On one hand, defective immune surveillance
allows endometrial cells to implant on pelvic structures, while on the
other hand endometriotic implants exhibit a hyper immune response, causing
increased inflammation and scarring.
2001 Fertil Steril 75;1:1-10
Lebovic, D. I., Mueller, M. D.,
and Taylor, R. N.
11076096 JA
Autoimmune response in women
with endometriosis
Women with grade III
endometriosis had a 45.4% incidence of anti-endometrial antibodies.
Presence of these antibodies was correlated with endometriosis severity.
2000 Am J Reprod Immunol
44;4:236-41
Iborra, A., Palacio, J. R.,
Ulcova-Gallova, Z., and Martinez, P.
10994636 R,T
Autoimmunity in endometriosis:
relevance to infertility
Details the specific antigens
to which endometriosis patients have autoimmune reactions, some of which
inhibit sperm motility.
2000 Am J Reprod Immunol
44;2:89-95
Mathur, S. P.
10360261 JA
Immune abnormalities in
endometriosis compromising fertility in IVF-ET patients
Endometriosis patients
exhibited several alloimmune and autoimmune differences compared with
women with unexplained infertility without endometriosis, including a
significant increase in antiphospholipid antibodies (48% vs. 30.6%).
Immune evaluation is recommended by authors prior to assisted
reproduction.
1999 J Reprod Med 44;5:458-64
Lucena, E. and Cubillos, J.
10394096 JA
Increased natural killer cell
activities in patients treated with gonadotropin releasing hormone agonist
Endometriosis patients have a
known decrease in natural killer (NK) cell activity. Treatment with a GnRH
antagonist significantly increased NK cell activity (37.7% to 50.8%),
independent of serum estradiol level.
1999 Gynecol Obstet Invest
48;1:66-8
Umesaki, N., Tanaka, T.,
Miyama, M., Mizuno, K., Kawamura, N., and Ogita, S.
3453197 JA
Endometriosis: a comparison of
associated disease histories
Women with endometriosis who
also had a family member with endometriosis had significantly increased
incidences of autoimmune diseases, allergies, vaginal yeast infections,
and food sensitivities.
1986 Am J Prev Med 2;6:324-9
Lamb, K. and Nichols, T. R.
10884535 JA
Environmental influence on
reproductive health
Discusses environmental
pollution in the workplace and at home acting as endocrine disrupters,
implicated in infertility, menstrual irregularities, spontaneous
abortions, birth defects, endometriosis and breast cancer. Lists how to
take an environmental exposure history.
2000 Int J Gynaecol Obstet
70;1:69-75
Bhatt, R. V.
[Top]
Cancer issues
[Cancer related to endometriosis is extremely uncommon.
However, the importance of exploring this relationship is that
much of the research being done now on cancer with
regards to immune therapy and decreasing blood supply has already been
shown to be of benefit to endometriosis patients, and will be used more
extensively in the near future.]
11696444 JA
Identification of an invasive,
N-cadherin-expressing epithelial cell type in endometriosis using a new
cell culture model
Investigation of cell lines
obtained from endometriosis patients showed that these cells exhibited
many features found in cancer micrometastases.
2001 Am J Pathol 159;5:1839-52
Zeitvogel, A., Baumann, R., and
Starzinski-Powitz, A.
11293158 JA
Malignancy in endometriosis:
frequency and comparison of ovarian and extraovarian types
Reviews the association between
endometriosis and pelvic cancers.
2001 Int J Gynecol Pathol
20;2:133-9
Stern, R. C., Dash, R.,
Bentley, R. C., Snyder, M. J., Haney, A. F., and Robboy, S. J.
10469746 R,T
Possible role of ovarian
epithelial inflammation in ovarian cancer
Discusses the possible role
that inflammation may play in ovarian cancer. Ovulation, asbestos and talc
exposure, endometriosis, and pelvic inflammatory disease, which all cause
inflammatory reactions, are risk factors for ovarian cancer.
1999 J Natl Cancer Inst
91;17:1459-67
Ness, R. B. and Cottreau, C.
11585420 JA
Endometriosis-associated
ovarian carcinoma (EAOC): an entity distinct from other ovarian carcinomas
as suggested by a nested case-control study
Endometriosis-associated
ovarian carcinoma is uncommon, thought to be approximately 1%. This study
demonstrated that these patients had better prognosis, lower grade lesions
and less chance of residual tumor than ovarian cancer not associated with
endometriosis.
2001 Gynecol Oncol 83;1:100-8
Erzen, M., Rakar, S., Klancnik,
B., Syrjanen, K., and Klancar, B.
11163832 JA
Microsatellite DNA assays
reveal an allelic imbalance in p16(Ink4), GALT, p53, and APOA2 loci in
patients with endometriosis
DNA analysis of endometriotic
implants from premenopausal women showed 36.4% exhibited genetic
abnormalities. There was a three-fold increase in these abnormalities
going from stage II disease to stage III & IV disease.
2001 Fertil Steril 75;1:160-5
Goumenou, A. G., Arvanitis, D.
A., Matalliotakis, I. M., Koumantakis, E. E., and Spandidos, D. A.
10907178 JA
Benign, borderline, and
malignant endometrioid neoplasia arising in endometriosis in association
with tamoxifen therapy
One of the risks of tamoxifen
is causing endometrial cancer of the uterus. This report describes benign,
borderline and cancerous endometrial implants arising in endometriosis
after tamoxifen use.
2000 Int J Gynecol Pathol
19;3:276-9
McCluggage, W. G., Bryson, C.,
Lamki, H., and Boyle, D. D.
11255562 R,T
Angiogenesis and its control in
the female reproductive system
Discussion of the potential use
of anti-angiogenesis agents (decrease blood supply) in reproduction,
including use involving birth control, cancer, endometriosis and fibroids.
2000 Br Med Bull 56;3:787-97
Fraser, H. M. and Lunn, S. F.
|
